Dr. Sheetal Karnik is a registered patent agent with the United States Patent and Trademark Office. She has a Ph.D in Molecular and Cellular Biology and post-doctoral research experience in immunology, clinical trials and protein biochemistry. She has published multiple research articles in International Science journals and has been invited to present her research at various International conferences. She has worked in the Agri-food industry as Director of Global Innovations and Technology and her expertise has been in product innovation and development. Her unique skill set includes knowledge and expertise of multiple disciplines in biological sciences.
Dr. Karnik received her Doctorate of Philosophy in Molecular and Cellular Biology from Arizona State University and was awarded ‘Student of the Year’ in the program. She has a Masters in Plant Biochemistry and Physiology from University of Mumbai. She received Bachelors in Science in Plant Biology from University of Mumbai, India.
Schwartz ES, Zhang W, Karnik SK, Laine PS, Reaven PD (2012) A novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation: nutrient modification of the innate immune system. Arteriosclerosis, Thrombosis and Vascular Biology (in review)
Schwartz ES, Zhang W, Karnik SK, Borwege S, Anand VR, Laine PS, Su Y, Reaven PD (2010) Nutrient modification of innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation, Arteriosclerosis, Thrombosis and Vascular Biology Apr 30 (4): 802-8
Laine PS, Schwartz ES, Wang Y, Zhang W, Karnik SK, Musi N, Reaven PD (2007) Palmitic acid induces IP-10 expression in human macrophages via NF-kB activation. Biochemical and Biophysical Research Communications 358 (1): 150-155
Karnik SK, Trelease RN (2007) Arabidopsis peroxin 16 trafficks through the ER and an intermediate compartment to pre-existing peroxisomes via overlapping molecular targeting signals. Journal of Experimental Botany 58 (7) 1677-1693
Karnik SK, Trelease RN (2005) Arabidopsis thaliana Peroxin 16 (AtPex16p) Coexists at Steady State in Peroxisomes and Endoplasmic Reticulum. Plant Physiology 138: 1967-1981
Lisenbee CS, Karnik SK, Trelease RN (2003) Overexpression and mislocalization of a tail-anchored GFP redefines the identity of peroxisomal ER. Traffic 4:491-501
Weiyang Zhang, Eric Schwartz, Paska Permana, Sheetal Karnik, Peter Reaven (2008) Pioglitazone Inhibits the Expression and Functional Consequences of Inflammatory Cytokines from Both Monocytes and Lymphocytes in Patients with Impaired Glucose Tolerance. American Diabetes Association (Poster Session: Complications – Macrovascular – Atherosclerotic CVD and Human Diabetes)
Karnik SK, Trelease RN (2004) ER is the primary sorting compartment for the post-translational trafficking of AtPex16p to peroxisomes in suspension-cultured cells. Plant Biology supplement p.149-150, Abstract 638 (Poster paper)
Karnik SK, Trelease RN (2003) Two Distinct (Non-Overlapping) Targeting Signals Sort AtPex16p to Peroxisomes Indirectly Via a Pre-Peroxisomal Compartment. Plant Biology supplement p. 243, Abstract 1228. (Poster paper)
Karnik SK, Trelease RN (2003) Sorting of AtPex16p to a Pre-peroxisomal Compartment and Peroxisomes in Suspension Cultured Plant Cells. Proceedings of the 18th Annual Molecular and Cellular Biology Meetings, Tontozona, AZ. (Oral presentation)
Karnik SK, Trelease RN (2002) Sorting of Transiently Expressed AtPex16p to peroxisomes in Suspension Cultured Plant Cells. Plant Biology supplement p. 72, Abstract 216. (Poster paper)
Heinze M, Lisenbee CS, Uchida M, Karnik SK, Trelease RN (2002) Variations in Sorting Pathways for Peroxins and Other Peroxisomal Membrane Proteins. 13th International Conference on Arabidopsis Research Supplement, Abstract 7-71. (Poster paper)
Karnik SK, Lisenbee CS, Trelease RN (2001) Do Arabidopsis Suspension Cells Constitute a Suitable Model Cell System for Protein Trafficking Studies? Plant Biology supplement p. 46, Abstract 112. (Poster paper)
Karnik SK, Lisenbee CS, Trelease RN (2001) Arabidopsis Suspension Cells are a Preferred Cell System for Plant Protein Trafficking Studies. Proceedings of the 16th Annual Molecular and Cellular Biology Meetings, Tontozona, AZ. (Oral presentation)
Karnik SK, Lisenbee CS, Trelease RN (2001) Immunofluorescence Comparison of Organelles in Suspension Cultured Arabidopsis and BY-2 Cells. Proceedings of the Second Annual Life and Earth Science Graduate research Symposium. (Oral presentation)
Director of Global Innovation and Technology
World Wide Wheat, Scottsdale, Arizona
- Successfully setup and established the company’s product development and research program for Wheat, Barley and Oats
- Provided leadership for new product initiatives, product concept development, project plans, and research protocols
- Secured external funding to leverage organizational research investment
- Developed distinct health related new product platforms which allowed the company to rebrand and reposition itself into the emerging “Health and Wellness” food categories
- Explored new business development opportunities and procured firm leads
- Established relations with scientific community to build on opportunities to ensure implementation of research plans and priorities.
Post Doctoral Research Associate
Department of Medicine and Endocrinology, Carl T. Hayden’s Medical Research Center, Veterans Affairs Medical Hospital, Phoenix, Arizona.
- Published research papers that identified molecular mechanisms for connection between obesity, type 2 diabetes and increased risk of cardiovascular disease (CVD) for different kinds of Fats (saturated vs. Unsaturated Fats).
- Determined potential therapeutic targets to treat or prevent CVDs in clinical trials
- Elucidated a novel pathway in increasing the inflammatory response related to CVDs in diabetics using a combination of fluorescent techniques, ELISA and PCR strategies
- Opened new avenues to identifying molecular targets as well as potential therapies for patients with diabetes and heart disease
Graduate Research Assistant
Arizona State University, Tempe, Arizona.
- Published research papers for protein trafficking pathway of a peroxin Pex16 within a cell
- Discovered the involvement of Endoplasmic Reticulum (ER) in sorting of Pex16 to peroxisomes
- Successfully mutated Pex16 signals that traffic to peroxisomes through ER
- Published research finally answered a hotly debated topic of involvement of ER in peroxisomal biogenesis thus proving that peroxisomes are semi-autonomous organelles and setting precedence for further research in this field.
U.S. Patent and Trademark office, Registered Patent Agent
Student of the Year in Molecular and Cell Biology (2003-2004), Arizona State University, Tempe, Arizona
Best Student of the Year (1995-1996), Kapila Khandwala College, Mumbai, India
Ranked 1st (among 600 students) in Masters of Science Degree examination, University of Mumbai, India
Ranked 5th (amongst 1800 students) in Bachelor of Education Degree examination, University of Mumbai, India.
Graduate College Award for 2003-2004 academic year, Arizona State University, Tempe, Arizona
Graduate Academic Scholarship for 2001-2003 academic year, Arizona State University, Tempe, Arizona
Graduate Assistant Health Insurance Scholarship 2000-2005
American Association of Cereal Chemists (AACC)
Dietary Fiber Technical Committee: AACC
Spring Wheat Technical Committee: Wheat Quality Council
Tortilla Industry Association
American Society of Plant Biologists